The aim of the study was to develop a reservoir-type transdermal patch for a controlled delivery of dexibuprofen and to evaluate\nits in vivo anti-inflammatory activity in Albino Wistar rats. In order to develop these patches, six formulations of dexibuprofen\nmicroemulsion comprising ethyl oleate, Tween 80: PG (2 : 1), and water were prepared by simplex lattice design and characterized.\nThe reservoir compartment was filled with these microemulsions and in vitro release and skin permeation were assessed. The\noptimized patch was obtained on the basis of the responses:
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